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Sacituzumab govitecan

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Sacituzumab govitecan is a medicine used to treat certain types of cancer. It's a type of treatment called an antibody-drug conjugate, which means it combines two different types of substances to fight cancer cells more effectively.

 

let's break down what sacituzumab govitecan is made of:

 

1. **Antibody**: The "sacituzumab" part of the medicine is an antibody. An antibody is a protein made by the immune system that can recognize and attach to specific proteins on the surface of cells. In this case, sacituzumab targets a protein called Trop-2, which is found on the surface of many cancer cells.

 

2. **Drug**: The "govitecan" part is the drug component of the medicine. It's a chemotherapy drug called SN-38, which is a powerful substance that can kill cancer cells.

 

Now, let's talk about how sacituzumab govitecan works:

 

When someone is given sacituzumab govitecan through an infusion (a slow drip into a vein), the antibody part of the medicine attaches to the Trop-2 proteins on the surface of cancer cells. This is like putting a "target" on the cancer cells, making them easier to find.

 

Once the sacituzumab govitecan attaches to the cancer cells, it releases the chemotherapy drug, SN-38, directly into the cancer cells. This is important because it helps to minimize damage to healthy cells, which can reduce side effects.

 

Once inside the cancer cells, SN-38 interferes with their ability to grow and divide, ultimately causing them to die. This helps to shrink tumors and slow down the progression of the cancer.

Sacituzumab govitecan is currently approved for the treatment of certain types of advanced or metastatic cancers, including triple-negative breast cancer and metastatic urothelial cancer. It's typically used when other treatments have stopped working or when the cancer has spread to other parts of the body.

 

Like all medicines, sacituzumab govitecan can cause side effects. Some common side effects may include nausea, diarrhea, fatigue, and low levels of certain blood cells. However, the side effects of sacituzumab govitecan are often milder compared to traditional chemotherapy drugs because it specifically targets cancer cells.

 

In summary, sacituzumab govitecan is a type of targeted therapy that combines an antibody and a chemotherapy drug to effectively attack cancer cells while minimizing damage to healthy cells. It's an important treatment option for certain types of advanced cancers and can help improve outcomes for patients.

 

Have any queries, book a consultation with our Oncology Clinical Specialist

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How does this medicine work

Sacituzumab govitecan works like a double agent against cancer cells. It's made of two parts: an antibody and a chemotherapy drug.

First, the antibody part of the medicine acts like a homing device. It latches onto a specific protein called Trop-2, which is found on the surface of cancer cells. This helps the medicine find its target.

Once the medicine attaches to the cancer cells, it releases the chemotherapy drug, SN-38, directly into them. This drug is like a powerful poison for cancer cells. It disrupts their ability to grow and multiply, eventually causing them to die.

So, sacituzumab govitecan is like a smart missile that homes in on cancer cells, delivering a lethal blow to them while sparing healthy cells as much as possible. This helps to shrink tumors and slow down the spread of cancer throughout the body.

Have any queries, book a consultation with our Oncology Clinical Specialist

What is useful for?

Sacituzumab govitecan is useful for treating certain types of cancer, especially when they have spread to other parts of the body or when other treatments haven't worked well enough. It's approved for use in cancers like:

1. **Triple-negative breast cancer**: This is a type of breast cancer that doesn't have certain hormone receptors and doesn't respond to hormone therapy or drugs like Herceptin.

2. **Metastatic urothelial cancer**: This is cancer that starts in the bladder or other parts of the urinary system and has spread to other areas.

Sacituzumab govitecan can be a helpful option for people with these types of cancer, as it specifically targets cancer cells while causing fewer side effects on healthy cells compared to traditional chemotherapy. It works by slowing down the growth of cancer cells and shrinking tumors, which can improve symptoms and prolong life for some patients.

Visit our Research Division Doctors in Online Consults for more details.

What if you miss the dose?

If you miss a dose of Sacituzumab govitecan, it's important to contact your healthcare provider right away. They will advise you on what to do next. Usually, if you miss a dose, our doctor will help you reschedule the treatment as soon as possible. It's important not to try to make up for the missed dose by taking extra medicine unless your doctor tells you to. Following our doctor's instructions is crucial for getting the most benefit from your treatment and staying safe.

Please book a consultation with our Oncology Clinical Specialist to know more about what happens if you miss the dose.

Will there be Side Effects

Sacituzumab govitecan can cause side effects. Some common side effects include:

1. **Nausea and vomiting**: Feeling sick to your stomach and throwing up.
2. **Diarrhea**: Having loose or watery bowel movements.
3. **Fatigue**: Feeling very tired or weak.
4. **Decreased appetite**: Not feeling hungry or wanting to eat less.
5. **Low blood cell counts**: This can lead to anemia (low red blood cells), which can cause fatigue and weakness, or neutropenia (low white blood cells), which can increase the risk of infections.

These side effects can vary from person to person and may range from mild to severe. It's important to tell our doctor about any side effects you experience, as they can provide guidance on managing them and may adjust your treatment if needed.

Have any queries, book a consultation with our Oncology Clinical Specialist

Tell us if you are taking other medicines like:-

 

If you're taking other medicines along with Sacituzumab govitecan, it's important to let our doctor know. Some medicines might interact with Sacituzumab govitecan, which means they can affect how well it works or cause more side effects.

Our doctor can check if any of the medicines you're taking might interact with Sacituzumab govitecan and make sure it's safe for you to take them together. It's always best to talk to our doctor before starting or stopping any medicines, including prescription drugs, over-the-counter medicines, and supplements. That way, you can make sure you're getting the most benefit from your treatment while staying safe.

Have any queries, book a consultation with our Oncology Clinical Specialist

Safety Advice : Pregnancy, Liver or Kidney Damaged

It's important to talk to our doctor if you're pregnant, planning to become pregnant, or breastfeeding before starting Sacituzumab govitecan. This medicine may harm an unborn baby, so your doctor can help you decide if the benefits of taking Sacituzumab govitecan outweigh the risks during pregnancy or breastfeeding.

If you have liver or kidney problems, it's also important to be cautious when using Sacituzumab govitecan. Your liver and kidneys help remove medicines from your body, so if they're not working well, Sacituzumab govitecan might build up in your body and cause more side effects. Our doctor can monitor your liver and kidney function and adjust your Sacituzumab govitecan dosage if needed to keep you safe.

Always follow our doctor's advice and instructions carefully to ensure the safe and effective use of Sacituzumab govitecan for your specific situation.

Have any queries, book a consultation with our Oncology Clinical Specialist

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